Unfortunately in some cases, the symptoms may not even become present until the condition is critical so this makes knowing and recognizing the symptoms crucial. Here are the top 10 signs of kidney disease that you need to be aware about: 1. Changes in urinary function The first tell-tale sign of kidney disease is changes in the amount of how many times you urinate. You can see a dramatic increase or decrease in the amount of urine you pass at times, you might also notice your urine change into a darker color, you might also feel the extreme urge to urinate but unable to when you get to the restroom.